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KMID : 0358320150560080565
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Korean Journal of Urology
2015 Volume.56 No. 8 p.565 ~ p.571
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Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia
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Lee Dong-Hyun
Lee Chun-Woo
Kwon Taek-Min
You Dal-San
Jeong In-Gab
Hong Jun-Hyuk
Ahn Han-Jong
Kim Choung-Soo
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Abstract
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Purpose: To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN).
Materials and Methods: We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive neoadjuvant or adjuvant therapy and were followed up for more than 1 year were included. The cohort was divided into two groups-patients with and without HGPIN-and their characteristics were compared. The Cox proportional hazards model was used to analyze factors affecting BCR.
Results: In total, 652 study patients (86.7%) had HGPIN. There were no significant differences in preoperative factors between the two groups, including age (p=0.369) and preoperative prostate-specific antigen concentration (p=0.234). Patients with HGPIN had a higher Gleason score (p=0.012), more frequent multiple tumor (p=0.013), and more perineural invasion (p=0.012), but no other postoperative pathologic characteristics were significantly different between the two groups. There were no significant differences in BCR (13.0% vs. 11.5%, p=0.665) and HGPIN was not associated with BCR (p=0.745). In multivariate analysis, only the T stage (p<0.001) was associated with BCR.
Conclusions: PCa patients with HGPIN have a higher Gleason score, more frequent multiple tumors, and more perineural invasion than those without HGPIN. The presence of HGPIN is not an independent predictor of BCR.
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KEYWORD
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Prostatectomy , Prostatic intraepithelial neoplasia , Prostatic neoplasms
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